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The cell's DNA is packaged into chromosomes. This packaging is necesary for efficient segregation of chromosomes at mitosis. How is the condensation of interphase chromatin into mitotic chromosomes regulated? What are the proteins that make up the mitotic chromosome? The kinetochore is a structure located at the centromere of each chromosome that binds to the microtubules of the mitotic spindle and mediates the segregation of sister chromatids at mitosis. What are the proteins localized to the kinetochore? Does the kinetochore generate force? This image, taken by Arshad Desai, shows chromosomes assembled in vitro from Xenopus sperm added to a mitotic Xenopus egg extract. DNA is shown in blue, and a kinetochore component, CENP-E, is shown in red. |
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