Guillaume Charras Guillaume is currently a Lecturer at University College, London, and the London Center for Nanotechnology. He is interested in the biophysics of living cells both at the single cell and tissue level.

Email: g.charras * ucl.ac.uk Webpage: http://www.london-nano.com/content/lcndirectory/charrasguillaume/

Publications Charras GT, Mitchison TJ, Mahadevan L. Animal cell hydraulics. J Cell Sci. 2009 Sep 15;122(Pt 18):3233-41. Epub 2009 Aug 18. PubMed Kueh HY, Charras GT, Mitchison TJ, Brieher WM. Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers. J Cell Biol. 2008 Jul 28;182(2):341-53. PubMed Mitchison TJ, Charras GT, Mahadevan L. Implications of a poroelastic cytoplasm for the dynamics of animal cell shape. Semin Cell Dev Biol. 2008 Jun;19(3):215-23. Epub 2008 Feb 7. PubMed Charras GT, Coughlin M, Mitchison TJ, Mahadevan L. Life and Times of a Cellular Bleb. Biophys J. 2007 Oct 5; [Epub ahead of print] PubMed Charras GT, Hu CK, Coughlin M, Mitchison TJ. Reassembly of contractile actin cortex in cell blebs. J Cell Biol. 2006 Nov 6;175(3):477-90. PubMed Charras GT, Yarrow JC, Horton MA, Mahadevan L, Mitchison TJ. Non-equilibration of hydrostatic pressure in blebbing cells. Nature. 2005 May 19;435(7040):365-9. PubMed Full Text Yarrow JC, Totsukawa G, Charras GT, Mitchison TJ. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem Biol. 2005 Mar;12(3):385-95. PubMed Full Text Charras GT, Williams BA, Sims SM, Horton MA. Estimating the sensitivity of mechanosensitive ion channels to membrane strain and tension. Biophys J. 2004 Oct;87(4):2870-84. PubMed Lehenkari PP, Charras GT, Nesbitt SA, Horton MA. New technologies in scanning probe microscopy for studying molecular interactions in cells. Expert Rev Mol Med. 2000 Mar 8;2000:1-19. PubMed Charras GT, Horton MA. Determination of cellular strains by combined atomic force microscopy and finite element modeling. Biophys J. 2002 Aug;83(2):858-79. PubMed Charras GT, Horton MA. Single cell mechanotransduction and its modulation analyzed by atomic force microscope indentation. Biophys J. 2002 Jun;82(6):2970-81. PubMed Koontz JT, Charras GT, Guldberg RE. A microstructural finite element simulation of mechanically induced bone formation. J Biomech Eng. 2001 Dec;123(6):607-12. PubMed Charras GT, Lehenkari PP, Horton MA. Atomic force microscopy can be used to mechanically stimulate osteoblasts and evaluate cellular strain distributions. Ultramicroscopy. 2001 Jan;86(1-2):85-95. PubMed Lehenkari PP, Charras GT, Nykanen A, Horton MA. Adapting atomic force microscopy for cell biology. Ultramicroscopy. 2000 Feb;82(1-4):289-95. PubMed Charras GT, Guldberg RE. Improving the local solution accuracy of large-scale digital image-based finite element analyses. J Biomech. 2000 Feb;33(2):255-9. PubMed Guldberg RE, Hollister SJ, Charras GT. The accuracy of digital image-based finite element models. J Biomech Eng. 1998 Apr;120(2):289-95. PubMed