Hao Yuan Kueh I study mechanisms of actin turnover in cells using a combination of microscopy, image analysis, mathematical modeling.

Email: kueh * fas.harvard.edu

Publications Kueh HY, Mitchison TJ. Structural plasticity in actin and tubulin polymer dynamics. Science. 2009 Aug 21;325(5943):960-3. PubMed Kueh HY, Brieher WM, Mitchison TJ. Dynamic stabilization of actin filaments. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16531-6. Epub 2008 Oct 17. PubMed Kueh HY. Monitoring actin disassembly with time-lapse microscopy. J Vis Exp. 2006 Nov 8;(1):66. PubMed Kueh HY, Charras GT, Mitchison TJ, Brieher WM. Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers. J Cell Biol. 2008 Jul 28;182(2):341-53. PubMed Niethammer P, Kueh HY, Mitchison TJ. Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm. Curr Biol. 2008 Apr 22;18(8):586-91. Epub 2008 Apr 10. PubMed Galkin VE, Orlova A, Brieher W, Kueh HY, Mitchison TJ, Egelman EH. Coronin-1A Stabilizes F-Actin by Bridging Adjacent Actin Protomers and Stapling Opposite Strands of the Actin Filament. J Mol Biol. 2007 Dec 8; [Epub ahead of print] PubMed Levine J, Kueh HY, Mirny L. Intrinsic fluctuations, robustness, and tunability in signaling cycles. Biophys J. 2007 Jun 15;92(12):4473-81. Epub 2007 Mar 30. PubMed Brieher WM, Kueh HY, Ballif BA, Mitchison TJ. Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. J Cell Biol. 2006 Oct 23;175(2):315-24. PubMed Burish MJ, Kueh HY, Wang SS. Brain architecture and social complexity in modern and ancient birds. Brain Behav Evol. 2004;63(2):107-24. Epub 2003 Dec 19. PubMed Vilar JM, Kueh HY, Barkai N, Leibler S. Mechanisms of noise-resistance in genetic oscillators. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5988-92. Epub 2002 Apr 23. PubMed