Dan Needleman

Email: daniel_needleman * hms.harvard.edu

Publications Needleman DJ, Xu Y, Mitchison TJ. Pin-hole array correlation imaging: highly parallel fluorescence correlation spectroscopy. Biophys J. 2009 Jun 17;96(12):5050-9. PubMed Wuhr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ. How does a millimeter-sized cell find its center? Cell Cycle. 2009 Apr 9;8(8) [Epub ahead of print] PubMed Gatlin JC, Matov A, Groen AC, Needleman DJ, Maresca TJ, Danuser G, Mitchison TJ, Salmon ED. Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules. Curr Biol. 2009 Feb 24;19(4):287-96. PubMed Wuhr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ. Evidence for an upper limit to mitotic spindle length. Curr Biol. 2008 Aug 26;18(16):1256-61. PubMed Needleman DJ. Plasmid segregation: is a total understanding within reach? Curr Biol. 2008 Mar 11;18(5):R212-4. PubMed Raviv U, Nguyen T, Ghafouri R, Needleman DJ, Li Y, Miller HP, Wilson L, Bruinsma RF, Safinya CR. Microtubule protofilament number is modulated in a step-wise fashion by the charge density of an enveloping layer. Biophys J. 2006 Oct 6; [Epub ahead of print] PubMed Safinya CR, Ewert K, Ahmad A, Evans HM, Raviv U, Needleman DJ, Lin AJ, Slack NL, George C, Samuel CE. Cationic liposome-DNA complexes: from liquid crystal science to gene delivery applications. Philos Transact A Math Phys Eng Sci. 2006 Oct 15;364(1847):2573-96. PubMed Needleman DJ, Ojeda-Lopez MA, Raviv U, Ewert K, Miller HP, Wilson L, Safinya C. Radial Compression of Microtubules and the Mechanism of Action of Taxol and Associated Proteins. Biophys J. 2005 Aug 12; [Epub ahead of print] PubMed Raviv U, Needleman DJ, Li Y, Miller HP, Wilson L, Safinya CR. Cationic liposome-microtubule complexes: pathways to the formation of two-state lipid-protein nanotubes with open or closed ends. Proc Natl Acad Sci U S A. 2005 Aug 9;102(32):11167-72. Epub 2005 Jul 29. PubMed Needleman DJ, Ojeda-Lopez MA, Raviv U, Ewert K, Jones JB, Miller HP, Wilson L, Safinya CR. Synchrotron X-ray diffraction study of microtubules buckling and bundling under osmotic stress: a probe of interprotofilament interactions. Phys Rev Lett. 2004 Nov 5;93(19):198104. Epub 2004 Nov 4. PubMed Needleman DJ, Ojeda-Lopez MA, Raviv U, Miller HP, Wilson L, Safinya CR. Higher-order assembly of microtubules by counterions: from hexagonal bundles to living necklaces. Proc Natl Acad Sci U S A. 2004 Nov 16;101(46):16099-103. Epub 2004 Nov 8. PubMed Fygenson DK, Needleman DJ, Sneppen K. Variability-based sequence alignment identifies residues responsible for functional differences in alpha and beta tubulin. Protein Sci. 2004 Jan;13(1):25-31. PubMed Monks SA, Needleman DJ, Miller C. Helical structure and packing orientation of the S2 segment in the Shaker K+ channel. J Gen Physiol. 1999 Mar;113(3):415-23. PubMed