Tim Mitchison Our experiences adopting Lorna in China Our experiences adopting Duncan in Cambodia

Email: timothy_mitchison * hms.harvard.edu

Publications Mitchison TJ, Mitchison HM. Cell biology: How cilia beat. Nature. 2010 Jan 21;463(7279):308-9. PubMed Needleman DJ, Groen A, Ohi R, Maresca T, Mirny L, Mitchison T. Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules. Mol Biol Cell. 2010 Jan;21(2):323-33. Epub 2009 Nov 25. PubMed Dumont S, Mitchison TJ. Force and length in the mitotic spindle. Curr Biol. 2009 Sep 15;19(17):R749-R761. PubMed Tsui M, Xie T, Orth JD, Carpenter AE, Rudnicki S, Kim S, Shamu CE, Mitchison TJ. An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor. PLoS One. 2009 Oct 5;4(10):e7339. PubMed Huang HC, Shi J, Orth JD, Mitchison TJ. Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle Assembly. Cancer Cell. 2009 Oct 6;16(4):347-58. PubMed Ozlu N, Monigatti F, Renard BY, Field CM, Steen H, Mitchison TJ, Steen JJ. Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Mol Cell Proteomics. 2009 Sep 28; [Epub ahead of print] PubMed Chang P, Coughlin M, Mitchison TJ. Interaction between Poly(ADP-ribose) and NuMA Contributes to Mitotic Spindle Pole Assembly. Mol Biol Cell. 2009 Sep 16; [Epub ahead of print] PubMed Kueh HY, Mitchison TJ. Structural plasticity in actin and tubulin polymer dynamics. Science. 2009 Aug 21;325(5943):960-3. PubMed Charras GT, Mitchison TJ, Mahadevan L. Animal cell hydraulics. J Cell Sci. 2009 Sep 15;122(Pt 18):3233-41. Epub 2009 Aug 18. PubMed Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nat Rev Drug Discov. 2009 Jul;8(7):567-78. PubMed Maresca TJ, Groen AC, Gatlin JC, Ohi R, Mitchison TJ, Salmon ED. Spindle Assembly in the Absence of a RanGTP Gradient Requires Localized CPC Activity. Curr Biol. 2009 Jun 17; [Epub ahead of print] PubMed Dumont S, Mitchison TJ. Compression Regulates Mitotic Spindle Length by a Mechanochemical Switch at the Poles. Curr Biol. 2009 Jun 17; [Epub ahead of print] PubMed Needleman DJ, Xu Y, Mitchison TJ. Pin-hole array correlation imaging: highly parallel fluorescence correlation spectroscopy. Biophys J. 2009 Jun 17;96(12):5050-9. PubMed A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Comment in: Nature. 2009 Jun 18;459(7249):921-3. Nature. 2009 Jun 18;459(7249):996-9. Epub 2009 Jun 3. PubMed Size and speed go hand in hand in cytokinesis. Comment on: Cell. 2009 May 29;137(5):926-37. Cell. 2009 May 29;137(5):798-800. PubMed Groen AC, Maresca TJ, Gatlin JC, Salmon ED, Mitchison TJ. Functional Overlap of Microtubule Assembly Factors in Chromatin-Promoted Spindle Assembly. Mol Biol Cell. 2009 Apr 15; [Epub ahead of print] PubMed Wuhr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ. How does a millimeter-sized cell find its center? Cell Cycle. 2009 Apr 9;8(8) [Epub ahead of print] PubMed Gatlin JC, Matov A, Groen AC, Needleman DJ, Maresca TJ, Danuser G, Mitchison TJ, Salmon ED. Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules. Curr Biol. 2009 Feb 24;19(4):287-96. PubMed Orth JD, Tang Y, Shi J, Loy CT, Amendt C, Wilm C, Zenke FT, Mitchison TJ. Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Mol Cancer Ther. 2008 Nov;7(11):3480-9. Epub 2008 Oct 30. PubMed Maloney KN, Fujita M, Eggert US, Schroeder FC, Field CM, Mitchison TJ, Clardy J. Actin-Aggregating Cucurbitacins from Physocarpus capitatus. J Nat Prod. 2008 Oct 30; [Epub ahead of print] PubMed Wuhr M, Mitchison TJ, Field CM. Mitosis: new roles for Myosin-x and actin at the spindle. Curr Biol. 2008 Oct 14;18(19):R912-4. PubMed Kueh HY, Brieher WM, Mitchison TJ. Dynamic stabilization of actin filaments. Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16531-6. Epub 2008 Oct 17. PubMed Wuhr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ. Evidence for an upper limit to mitotic spindle length. Curr Biol. 2008 Aug 26;18(16):1256-61. PubMed Kueh HY, Charras GT, Mitchison TJ, Brieher WM. Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers. J Cell Biol. 2008 Jul 28;182(2):341-53. PubMed Groen AC, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison TJ. A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly. J Cell Sci. 2008 Jul 15;121(Pt 14):2293-300. Epub 2008 Jun 17. PubMed Shi J, Orth JD, Mitchison T. Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5. Cancer Res. 2008 May 1;68(9):3269-76. PubMed Hu CK, Coughlin M, Field CM, Mitchison TJ. Cell polarization during monopolar cytokinesis. J Cell Biol. 2008 Apr 21;181(2):195-202. Epub 2008 Apr 14. PubMed Niethammer P, Kueh HY, Mitchison TJ. Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm. Curr Biol. 2008 Apr 22;18(8):586-91. Epub 2008 Apr 10. PubMed Mitchison TJ, Charras GT, Mahadevan L. Implications of a poroelastic cytoplasm for the dynamics of animal cell shape. Semin Cell Dev Biol. 2008 Jun;19(3):215-23. Epub 2008 Feb 7. PubMed Salic A, Mitchison TJ. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2415-20. Epub 2008 Feb 12. PubMed Galkin VE, Orlova A, Brieher W, Kueh HY, Mitchison TJ, Egelman EH. Coronin-1A Stabilizes F-Actin by Bridging Adjacent Actin Protomers and Stapling Opposite Strands of the Actin Filament. J Mol Biol. 2007 Dec 8; [Epub ahead of print] PubMed Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y. Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nat Chem Biol. 2008 Jan;4(1):59-68. Epub 2007 Dec 9. PubMed Irimia D, Charras G, Agrawal N, Mitchison T, Toner M. Polar stimulation and constrained cell migration in microfluidic channels. Lab Chip. 2007 Dec;7(12):1783-90. Epub 2007 Sep 4. PubMed Charras GT, Coughlin M, Mitchison TJ, Mahadevan L. Life and Times of a Cellular Bleb. Biophys J. 2007 Oct 5; [Epub ahead of print] PubMed Burbank KS, Mitchison TJ, Fisher DS. Slide-and-Cluster Models for Spindle Assembly. Curr Biol. 2007 Aug 14; [Epub ahead of print] PubMed Vrabioiu AM, Mitchison TJ. Symmetry of septin hourglass and ring structures. J Mol Biol. 2007 Sep 7;372(1):37-49. Epub 2007 Jun 9. PubMed Ohi R, Burbank K, Liu Q, Mitchison TJ. Nonredundant functions of Kinesin-13s during meiotic spindle assembly. Curr Biol. 2007 Jun 5;17(11):953-9. Epub 2007 May 17. PubMed Comment in: Nat Cell Biol. 2007 Mar;9(3):245-6. Erratum in: Nat Cell Biol. 2007 Apr;9(4):480. Nat Cell Biol. 2007 Mar;9(3):276-86. Epub 2007 Feb 11. PubMed Charras GT, Hu CK, Coughlin M, Mitchison TJ. Reassembly of contractile actin cortex in cell blebs. J Cell Biol. 2006 Nov 6;175(3):477-90. PubMed Burbank KS, Groen AC, Perlman ZE, Fisher DS, Mitchison TJ. A new method reveals microtubule minus ends throughout the meiotic spindle. J Cell Biol. 2006 Nov 6;175(3):369-75. PubMed Ribbeck K, Mitchison TJ. Meiotic spindle: sculpted by severing. Curr Biol. 2006 Nov 7;16(21):R923-5. PubMed Brieher WM, Kueh HY, Ballif BA, Mitchison TJ. Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. J Cell Biol. 2006 Oct 23;175(2):315-24. PubMed Vrabioiu AM, Mitchison TJ. Structural insights into yeast septin organization from polarized fluorescence microscopy. Nature. 2006 Sep 28;443(7110):466-9. PubMed Eggert US, Field CM, Mitchison TJ. Small molecules in an RNAi world. Mol Biosyst. 2006 Feb;2(2):93-6. Epub 2005 Dec 16. PubMed Burbank KS, Mitchison TJ. Microtubule dynamic instability. Curr Biol. 2006 Jul 25;16(14):R516-7. PubMed Eggert US, Mitchison TJ, Field CM. ANIMAL CYTOKINESIS: From Parts List to Mechanisms. Annu Rev Biochem. 2006 Jul 7;75:543-566. PubMed Eggert US, Mitchison TJ. Small molecule screening by imaging. Curr Opin Chem Biol. 2006 May 6; [Epub ahead of print] PubMed Ribbeck K, Groen AC, Santarella R, Bohnsack MT, Raemaekers T, Kocher T, Gentzel M, Gorlich D, Wilm M, Carmeliet G, Mitchison TJ, Ellenberg J, Hoenger A, Mattaj IW. NuSAP, a Mitotic RanGTP Target That Stabilizes and Cross-links Microtubules. Mol Biol Cell. 2006 Mar 29; [Epub ahead of print] PubMed De Wall SL, Painter C, Stone JD, Bandaranayake R, Wiley DC, Mitchison TJ, Stern LJ, Dedecker BS. Noble metals strip peptides from class II MHC proteins. Nat Chem Biol. 2006 Feb 26; [Epub ahead of print] PubMed Maliga Z, Mitchison TJ. Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. BMC Chem Biol. 2006 Feb 27;6(1):2 [Epub ahead of print] PubMed Comment in: Nat Chem Biol. 2005 Jul;1(2):68-9. Erratum in: Nat Chem Biol. 2005 Sep;1(4):234. Nat Chem Biol. 2005 Jul;1(2):112-9. Epub 2005 May 29. PubMed Eggert US, Field CM, Mitchison TJ. Small molecules in an RNAi world Mol. BioSyst. 2006 Feb 22;2:93-6. Full Text Chang P, Coughlin M, Mitchison TJ. Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nat Cell Biol. 2005 Oct 23; [Epub ahead of print] PubMed Mahadevan L, Mitchison TJ. Cell biology: powerful curves Nature. 2005 Jun 16;435(7044):895-7. PubMed Dorer RK, Zhong S, Tallarico JA, Wong WH, Mitchison TJ, Murray AW. A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes. Curr Biol. 2005 Jun 7;15(11):1070-6. PubMed Full Text Charras GT, Yarrow JC, Horton MA, Mahadevan L, Mitchison TJ. Non-equilibration of hydrostatic pressure in blebbing cells. Nature. 2005 May 19;435(7040):365-9. PubMed Full Text Mitchison TJ. Mechanism and function of poleward flux in Xenopus extract meiotic spindles. Philos Trans R Soc Lond B Biol Sci. 2005 Mar 29;360(1455):623-9. PubMed Full Text Yarrow JC, Totsukawa G, Charras GT, Mitchison TJ. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chem Biol. 2005 Mar;12(3):385-95. PubMed Full Text Mitchison TJ, Maddox P, Gaetz J, Groen A, Shirasu M, Desai A, Salmon ED, Kapoor TM. Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles. Mol Biol Cell. 2005 Mar 23; [Epub ahead of print] PubMed Full Text Perlman ZE, Mitchison TJ, Mayer TU. High-Content Screening and Profiling of Drug Activity in an Automated Centrosome-Duplication Assay. Chembiochem. 2005 Feb 4;6(2):218. PubMed Full Text Miyamoto DT, Perlman ZE, Burbank KS, Groen AC, Mitchison TJ. The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles. J Cell Biol. 2004 Dec 6;167(5):813-8. PubMed Full Text Chang P, Jacobson MK, Mitchison TJ. Poly(ADP-ribose) is required for spindle assembly and structure. Nature. 2004 Dec 2;432(7017):645-9. PubMed Full Text Perlman ZE, Mitchison TJ, Mayer TU. High-content screening and profiling of drug activity in an automated centrosome-duplication assay. Chembiochem. 2005 Jan;6(1):145-51. PubMed Mitchison TJ. Small-molecule screening and profiling by using automated microscopy. Chembiochem. 2005 Jan;6(1):33-9. PubMed Full Text Limouze J, Straight AF, Mitchison T, Sellers JR. Specificity of blebbistatin, an inhibitor of myosin II. J Muscle Res Cell Motil. 2004;25(4-5):337-41. PubMed Eggert US, Kiger AA, Richter C, Perlman ZE, Perrimon N, Mitchison TJ, Field CM. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol. 2004 Dec;2(12):e379. Epub 2004 Oct 5. PubMed Full Text Ramamurthy B, Yengo CM, Straight AF, Mitchison TJ, Sweeney HL. Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb. Biochemistry. 2004 Nov 23;43(46):14832-9. PubMed Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. Multidimensional drug profiling by automated microscopy. Science. 2004 Nov 12;306(5699):1194-8. PubMed Full Text Shirasu-Hiza M, Perlman ZE, Wittmann T, Karsenti E, Mitchison TJ. Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked. Curr Biol. 2004 Nov 9;14(21):1941-5. PubMed Full Text Valentine MT, Perlman ZE, Mitchison TJ, Weitz DA. Mechanical properties of Xenopus egg cytoplasmic extracts. Biophys J. 2005 Jan;88(1):680-9. Epub 2004 Oct 22. PubMed Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R. XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly. Curr Biol. 2004 Oct 26;14(20):1801-11. PubMed Full Text Straight AF, Field CM, Mitchison TJ. Anillin binds nonmuscle myosin II and regulates the contractile ring. Mol Biol Cell. 2005 Jan;16(1):193-201. Epub 2004 Oct 20. PubMed Full Text Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, Reddy AS, Saxton WM, Schliwa M, Scholey JM, Vale RD, Walczak CE, Wordeman L. A standardized kinesin nomenclature. J Cell Biol. 2004 Oct 11;167(1):19-22. PubMed Mitchison TJ, Maddox P, Groen A, Cameron L, Perlman Z, Ohi R, Desai A, Salmon ED, Kapoor TM. Bipolarization and poleward flux correlate during Xenopus extract spindle assembly. Mol Biol Cell. 2004 Dec;15(12):5603-15. Epub 2004 Sep 22. PubMed Yarrow JC, Perlman ZE, Westwood NJ, Mitchison TJ. A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods. BMC Biotechnol. 2004 Sep 9;4(1):21. PubMed Salic A, Waters JC, Mitchison TJ. Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell. 2004 Sep 3;118(5):567-78. PubMed Full Text Margalit DN, Romberg L, Mets RB, Hebert AM, Mitchison TJ, Kirschner MW, RayChaudhuri D. Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11821-6. PubMed Full Text Miller SC, Mitchison TJ. Synthesis and phenotypic screening of a Guanine-mimetic library. Chembiochem. 2004 Jul 5;5(7):1010-2. PubMed Full Text Valentine MT, Perlman ZE, Gardel ML, Shin JH, Matsudaira P, Mitchison TJ, Weitz DA. Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials. Biophys J. 2004 Jun;86(6):4004-14. PubMed Full Text Venkatesh N, Feng Y, DeDecker B, Yacono P, Golan D, Mitchison T, McKeon F. Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression. Proc Natl Acad Sci U S A. 2004 Jun 15;101(24):8969-74. Epub 2004 Jun 7. PubMed Carey KL, Westwood NJ, Mitchison TJ, Ward GE. A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii. Proc Natl Acad Sci U S A. 2004 May 11;101(19):7433-8. Epub 2004 May 3. PubMed Brieher WM, Coughlin M, Mitchison TJ. Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex. J Cell Biol. 2004 Apr 26;165(2):233-42. PubMed Full Text Ohi R, Sapra T, Howard J, Mitchison TJ. Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Mol Biol Cell. 2004 Jun;15(6):2895-906. Epub 2004 Apr 2. PubMed Corcoran LJ, Mitchison TJ, Liu Q. A novel action of histone deacetylase inhibitors in a protein aggresome disease model. Curr Biol. 2004 Mar 23;14(6):488-92. PubMed Tirnauer JS, Salmon ED, Mitchison TJ. Microtubule plus-end dynamics in Xenopus egg extract spindles. Mol Biol Cell. 2004 Apr;15(4):1776-84. Epub 2004 Feb 6. PubMed Theriot JA, Mitchison TJ. The nucleation-release model of actin filament dynamics in cell motility. Trends Cell Biol. 1992 Aug;2(8):219-22. PubMed Romberg L, Mitchison TJ. Rate-limiting guanosine 5'-triphosphate hydrolysis during nucleotide turnover by FtsZ, a prokaryotic tubulin homologue involved in bacterial cell division. Biochemistry. 2004 Jan 13;43(1):282-8. PubMed Full Text Vrabioiu AM, Gerber SA, Gygi SP, Field CM, Mitchison TJ. The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides. J Biol Chem. 2004 Jan 23;279(4):3111-8. Epub 2003 Nov 3. PubMed Miyamoto DT, Perlman ZE, Mitchison TJ, Shirasu-Hiza M. Dynamics of the mitotic spindle--potential therapeutic targets. Prog Cell Cycle Res. 2003;5:349-60. PubMed Ohi R, Coughlin ML, Lane WS, Mitchison TJ. An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Dev Cell. 2003 Aug;5(2):309-21. PubMed Full Text Canman JC, Cameron LA, Maddox PS, Straight A, Tirnauer JS, Mitchison TJ, Fang G, Kapoor TM, Salmon ED. Determining the position of the cell division plane. Nature. 2003 Aug 28;424(6952):1074-8. Epub 2003 Aug 6. PubMed Maddox P, Straight A, Coughlin P, Mitchison TJ, Salmon ED. Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics. J Cell Biol. 2003 Aug 4;162(3):377-82. PubMed Full Text Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Comment in: Cell. 2003 Jul 25;114(2):153-6. Cell. 2003 Jul 25;114(2):201-14. PubMed Zhai Q, Wang J, Kim A, Liu Q, Watts R, Hoopfer E, Mitchison T, Luo L, He Z. Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration. Neuron. 2003 Jul 17;39(2):217-25. PubMed Yarrow JC, Lechler T, Li R, Mitchison TJ. Rapid de-localization of actin leading edge components with BDM treatment. BMC Cell Biol. 2003 Jun 3;4(1):5. PubMed Yarrow JC, Feng Y, Perlman ZE, Kirchhausen T, Mitchison TJ. Phenotypic screening of small molecule libraries by high throughput cell imaging. Comb Chem High Throughput Screen. 2003 Jun;6(4):279-86. PubMed Full Text Feng Y, Yu S, Lasell TK, Jadhav AP, Macia E, Chardin P, Melancon P, Roth M, Mitchison T, Kirchhausen T. Exo1: a new chemical inhibitor of the exocytic pathway. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6469-74. Epub 2003 May 8. PubMed Shirasu-Hiza M, Coughlin P, Mitchison T. Identification of XMAP215 as a microtubule-destabilizing factor in Xenopus egg extract by biochemical purification. J Cell Biol. 2003 Apr 28;161(2):349-58. PubMed Straight AF, Cheung A, Limouze J, Chen I, Westwood NJ, Sellers JR, Mitchison TJ. Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science. 2003 Mar 14;299(5613):1743-7. PubMed Full Text McGrath JL, Eungdamrong NJ, Fisher CI, Peng F, Mahadevan L, Mitchison TJ, Kuo SC. The force-velocity relationship for the actin-based motility of Listeria monocytogenes. Curr Biol. 2003 Feb 18;13(4):329-32. PubMed Full Text Peterson JR, Mitchison TJ. Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton. Chem Biol. 2002 Dec;9(12):1275-85. PubMed Full Text Self- and actin-templated assembly of Mammalian septins. Comment in: Dev Cell. 2002 Dec;3(6):761-3. Dev Cell. 2002 Dec;3(6):791-802. PubMed Full Text Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ. EB1 targets to kinetochores with attached, polymerizing microtubules. Mol Biol Cell. 2002 Dec;13(12):4308-16. PubMed Full Text Macara IG, Baldarelli R, Field CM, Glotzer M, Hayashi Y, Hsu SC, Kennedy MB, Kinoshita M, Longtine M, Low C, Maltais LJ, McKenzie L, Mitchison TJ, Nishikawa T, Noda M, Petty EM, Peifer M, Pringle JR, Robinson PJ, Roth D, Russell SE, Stuhlmann H, Tanaka M, Tanaka T, Trimble WS, Ware J, Zeleznik-Le NJ, Zieger B. Mammalian septins nomenclature. Mol Biol Cell. 2002 Dec;13(12):4111-3. PubMed Cytoskeleton: what does GTP do for septins? Comment on: Curr Biol. 2002 Oct 29;12(21):1858-63. Curr Biol. 2002 Nov 19;12(22):R788-90. PubMed Walczak CE, Gan EC, Desai A, Mitchison TJ, Kline-Smith SL. The microtubule-destabilizing kinesin XKCM1 is required for chromosome positioning during spindle assembly. Curr Biol. 2002 Oct 29;12(21):1885-9. PubMed Full Text Tirnauer JS, Grego S, Salmon ED, Mitchison TJ. EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. Mol Biol Cell. 2002 Oct;13(10):3614-26. PubMed Full Text Maddox P, Desai A, Oegema K, Mitchison TJ, Salmon ED. Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos. Curr Biol. 2002 Oct 1;12(19):1670-4. PubMed Full Text Maliga Z, Kapoor TM, Mitchison TJ. Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chem Biol. 2002 Sep;9(9):989-96. PubMed Full Text Watanabe N, Mitchison TJ. Single-molecule speckle analysis of actin filament turnover in lamellipodia. Science. 2002 Feb 8;295(5557):1083-6. PubMed Full Text Cheung A, Dantzig JA, Hollingworth S, Baylor SM, Goldman YE, Mitchison TJ, Straight AF. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol. 2002 Jan;4(1):83-8. PubMed Full Text Kapoor TM, Mitchison TJ. Eg5 is static in bipolar spindles relative to tubulin: evidence for a static spindle matrix. J Cell Biol. 2001 Sep 17;154(6):1125-33. PubMed Full Text Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10624-9. PubMed Mitchison TJ. Psychosine, cytokinesis, and orphan receptors. Unexpected connections. J Cell Biol. 2001 Apr 16;153(2):F1-3. PubMed Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-xL. Comment in: Nat Cell Biol. 2001 Feb;3(2):E43-6. Nat Cell Biol. 2001 Feb;3(2):173-82. PubMed Mitosis: a history of division. Erratum in: Nat Cell Biol 2001 May;3(5):530. Nat Cell Biol. 2001 Jan;3(1):E17-21. PubMed Kapoor TM, Mayer TU, Coughlin ML, Mitchison TJ. Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J Cell Biol. 2000 Sep 4;150(5):975-88. PubMed Oegema K, Savoian MS, Mitchison TJ, Field CM. Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis. J Cell Biol. 2000 Aug 7;150(3):539-52. PubMed Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL. Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chem Biol. 2000 Apr;7(4):275-86. PubMed Full Text Taunton J, Rowning BA, Coughlin ML, Wu M, Moon RT, Mitchison TJ, Larabell CA. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP. J Cell Biol. 2000 Feb 7;148(3):519-30. PubMed Kirschner M, Gerhart J, Mitchison T. Molecular Vitalism Cell. 2000 Jan 7;100(1):79-88. PubMed Full Text Mallavarapu A, Sawin K, Mitchison T. A switch in microtubule dynamics at the onset of anaphase B in the mitotic spindle of Schizosaccharomyces pombe. Curr Biol. 1999 Dec 2;9(23):1423-6. PubMed Maddox P, Desai A, Salmon ED, Mitchison TJ, Oogema K, Kapoor T, Matsumoto B, Inoue S. Dynamic confocal imaging of mitochondria in swimming Tetrahymena and of microtubule poleward flux in Xenopus extract spindles. Biol Bull. 1999 Oct;197(2):263-5. PubMed Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR. Spatial control of actin polymerization during neutrophil chemotaxis. Nat Cell Biol. 1999 Jun;1(2):75-81. PubMed Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science. 1999 Oct 29;286(5441):971-4. PubMed Full Text Mallavarapu A, Mitchison T. Regulated actin cytoskeleton assembly at filopodium tips controls their extension and retraction. J Cell Biol. 1999 Sep 6;146(5):1097-106. PubMed Kapoor TM, Mitchison TJ. Allele-specific activators and inhibitors for kinesin. Proc Natl Acad Sci U S A. 1999 Aug 3;96(16):9106-11. PubMed Oegema K, Wiese C, Martin OC, Milligan RA, Iwamatsu A, Mitchison TJ, Zheng Y. Characterization of two related Drosophila gamma-tubulin complexes that differ in their ability to nucleate microtubules. J Cell Biol. 1999 Feb 22;144(4):721-33. PubMed Desai A, Verma S, Mitchison TJ, Walczak CE. Kin I kinesins are microtubule-destabilizing enzymes. Cell. 1999 Jan 8;96(1):69-78. PubMed Full Text Desai A, Murray A, Mitchison TJ, Walczak CE. The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro. Methods Cell Biol. 1999;61:385-412. PubMed Sharp DJ, McDonald KL, Brown HM, Matthies HJ, Walczak C, Vale RD, Mitchison TJ, Scholey JM. The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles. J Cell Biol. 1999 Jan 11;144(1):125-38. PubMed Frazier JA, Wong ML, Longtine MS, Pringle JR, Mann M, Mitchison TJ, Field C. Polymerization of purified yeast septins: evidence that organized filament arrays may not be required for septin function. J Cell Biol. 1998 Nov 2;143(3):737-49. PubMed Yoshihara HA, Chiellini G, Mitchison TJ, Scanlan TS. An efficient substitution reaction for the preparation of thyroid hormone analogues. Bioorg Med Chem. 1998 Aug;6(8):1179-83. PubMed Field CM, Oegema K, Zheng Y, Mitchison TJ, Walczak CE. Purification of cytoskeletal proteins using peptide antibodies. Methods Enzymol. 1998;298:525-41. PubMed Oegema K, Desai A, Wong ML, Mitchison TJ, Field CM. Purification and assay of a septin complex from Drosophila embryos. Methods Enzymol. 1998;298:279-95. PubMed Zheng Y, Wong ML, Alberts B, Mitchison T. Purification and assay of gamma tubulin ring complex. Methods Enzymol. 1998;298:218-28. PubMed Desai A, Mitchison TJ. Preparation and characterization of caged fluorescein tubulin. Methods Enzymol. 1998;298:125-32. PubMed Welch MD, Mitchison TJ. Purification and assay of the platelet Arp2/3 complex. Methods Enzymol. 1998;298:52-61. PubMed Desai A, Mitchison TJ. Tubulin and FtsZ structures: functional and therapeutic implications. Bioessays. 1998 Jul;20(7):523-7. PubMed Walczak CE, Vernos I, Mitchison TJ, Karsenti E, Heald R. A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity. Curr Biol. 1998 Jul 30-Aug 13;8(16):903-13. PubMed Full Text Mitchison TJ, Sawin KE, Theriot JA, Gee K, Mallavarapu A. Caged fluorescent probes. Methods Enzymol. 1998;291:63-78. PubMed Rosenblatt J, Mitchison TJ. Actin, cofilin and cognition. Nature. 1998 Jun 25;393(6687):739-40. PubMed Welch MD, Rosenblatt J, Skoble J, Portnoy DA, Mitchison TJ. Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science. 1998 Jul 3;281(5373):105-8. PubMed Full Text Desai A, Maddox PS, Mitchison TJ, Salmon ED. Anaphase A chromosome movement and poleward spindle microtubule flux occur At similar rates in Xenopus extract spindles. J Cell Biol. 1998 May 4;141(3):703-13. PubMed Desai A, Mitchison TJ. Microtubule polymerization dynamics. Annu Rev Cell Dev Biol. 1997;13:83-117. PubMed Full Text Mitchison TJ. Towards a pharmacological genetics. Chem Biol. 1994 Sep;1(1):3-6. PubMed Desai A, Deacon HW, Walczak CE, Mitchison TJ. A method that allows the assembly of kinetochore components onto chromosomes condensed in clarified Xenopus egg extracts. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12378-83. PubMed Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. J Cell Biol. 1997 Jul 28;138(2):375-84. PubMed Rappaport rules: cleavage furrow induction in animal cells. Comment on: Proc Natl Acad Sci U S A. 1997 May 13;94(10):5107-12. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4817-20. PubMed Rosenblatt J, Agnew BJ, Abe H, Bamburg JR, Mitchison TJ. Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails. J Cell Biol. 1997 Mar 24;136(6):1323-32. PubMed Cramer LP, Siebert M, Mitchison TJ. Identification of novel graded polarity actin filament bundles in locomoting heart fibroblasts: implications for the generation of motile force. J Cell Biol. 1997 Mar 24;136(6):1287-305. PubMed Walczak CE, Verma S, Mitchison TJ. XCTK2: a kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts. 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Cell. 1996 Jun 28;85(7):943-6. PubMed Full Text Field CM, al-Awar O, Rosenblatt J, Wong ML, Alberts B, Mitchison TJ. A purified Drosophila septin complex forms filaments and exhibits GTPase activity. J Cell Biol. 1996 May;133(3):605-16. PubMed Mitchison TJ, Cramer LP. Actin-based cell motility and cell locomotion. Cell. 1996 Feb 9;84(3):371-9. PubMed Full Text Belmont LD, Mitchison TJ. Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules. Cell. 1996 Feb 23;84(4):623-31. PubMed Full Text Mitchison TJ. Evolution of a dynamic cytoskeleton. Philos Trans R Soc Lond B Biol Sci. 1995 Sep 29;349(1329):299-304. PubMed Walczak CE, Mitchison TJ, Desai A. XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell. 1996 Jan 12;84(1):37-47. PubMed Full Text Zheng Y, Wong ML, Alberts B, Mitchison T. Nucleation of microtubule assembly by a gamma-tubulin-containing ring complex. Nature. 1995 Dec 7;378(6557):578-83. PubMed Hirano T, Mitchison TJ. Topoisomerase II does not play a scaffolding role in the organization of mitotic chromosomes assembled in Xenopus egg extracts. J Cell Biol. 1993 Feb;120(3):601-12. PubMed Cramer L, Mitchison TJ. Moving and stationary actin filaments are involved in spreading of postmitotic PtK2 cells. J Cell Biol. 1993 Aug;122(4):833-43. PubMed Theriot JA, Rosenblatt J, Portnoy DA, Goldschmidt-Clermont PJ, Mitchison TJ. Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts. Cell. 1994 Feb 11;76(3):505-17. PubMed Theriot JA, Mitchison TJ. The three faces of profilin. Cell. 1993 Dec 3;75(5):835-8. PubMed Hyman AA, Mitchison TJ. An assay for the activity of microtubule-based motors on the kinetochores of isolated Chinese hamster ovary chromosomes. Methods Cell Biol. 1993;39:267-76. PubMed Cramer LP, Mitchison TJ, Theriot JA. Actin-dependent motile forces and cell motility. 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Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material. Cell. 1983 Dec;35(3 Pt 2):621-9. PubMed Full Text Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature. 1984 Nov 15-21;312(5991):237-42. PubMed Mitchison T, Kirschner M. Microtubule assembly nucleated by isolated centrosomes. Nature. 1984 Nov 15-21;312(5991):232-7. PubMed Leslie RJ, Saxton WM, Mitchison TJ, Neighbors B, Salmon ED, McIntosh JR. Assembly properties of fluorescein-labeled tubulin in vitro before and after fluorescence bleaching. J Cell Biol. 1984 Dec;99(6):2146-56. PubMed Sambrook J, Greene R, Stringer J, Mitchison T, Hu SL, Botchan M. Analysis of the sites of integration of viral DNA sequences in rat cells transformed by adenovirus 2 or SV40. Cold Spring Harb Symp Quant Biol. 1980;44 Pt 1,:569-84. PubMed Botchan M, Stringer J, Mitchison T, Sambrook J. Integration and excision of SV40 DNA from the chromosome of a transformed cell. Cell. 1980 May;20(1):143-52. PubMed Mitchison TJ, Sedat J. Localization of antigenic determinants in whole Drosophila embryos. Dev Biol. 1983 Sep;99(1):261-4. PubMed Sambrook J, Botchan M, Hu SL, Mitchison T, Stringer J. Integration of viral DNA sequences in cells transformed by adenovirus 2 or SV40. Proc R Soc Lond B Biol Sci. 1980 Nov 19;210(1180):423-35. PubMed Evans L, Mitchison T, Kirschner M. Influence of the centrosome on the structure of nucleated microtubules. J Cell Biol. 1985 Apr;100(4):1185-91. PubMed Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation. J Cell Biol. 1985 Sep;101(3):766-77. PubMed Full Text Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. I. Microtubule nucleation and tubulin binding. J Cell Biol. 1985 Sep;101(3):755-65. PubMed Full Text Mitchison TJ, Kirschner MW. Isolation of mammalian centrosomes. Methods Enzymol. 1986;134:261-8. PubMed Full Text Kirschner MW, Mitchison T. Microtubule dynamics. Nature. 1986 Dec 18-31;324(6098):621. PubMed Mitchison T, Evans L, Schulze E, Kirschner M. Sites of microtubule assembly and disassembly in the mitotic spindle. Cell. 1986 May 23;45(4):515-27. PubMed Kirschner M, Mitchison T. Beyond self-assembly: from microtubules to morphogenesis. Cell. 1986 May 9;45(3):329-42. PubMed Full Text Koshland DE, Mitchison TJ, Kirschner MW. Polewards chromosome movement driven by microtubule depolymerization in vitro. Nature. 1988 Feb 11;331(6156):499-504. PubMed Full Text Kellogg DR, Mitchison TJ, Alberts BM. Behaviour of microtubules and actin filaments in living Drosophila embryos. Development. 1988 Aug;103(4):675-86. PubMed Mitchison T, Hyman A. Cell division. Kinetochores on the move. Nature. 1988 Nov 17;336(6196):200-1. PubMed Mitchison TJ. The role of microtubule polarity in the movement of kinesin and kinetochores. J Cell Sci Suppl. 1986;5:121-8. PubMed Mitchison T, Kirschner M. Cytoskeletal dynamics and nerve growth. Neuron. 1988 Nov;1(9):761-72 PubMed Full Text Mitchison TJ. Microtubule dynamics and kinetochore function in mitosis. Annu Rev Cell Biol. 1988;4:527-49. PubMed Kristofferson D, Mitchison T, Kirschner M. Direct observation of steady-state microtubule dynamics. J Cell Biol. 1986 Mar;102(3):1007-19. PubMed Full Text Mitchison TJ. Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence. J Cell Biol. 1989 Aug;109(2):637-52. PubMed Mitchison TJ. Mitosis: basic concepts. Curr Opin Cell Biol. 1989 Feb;1(1):67-74. PubMed Chain BM, Mitchison NA, Mitchison TJ, Davies DH, Marcinkiewicz J. Antigen processing: current issues, exceptional cases (Thy 1 alloantigen, MHC class-II-restricted cytolytic T cells), and implications for vaccine development. J Autoimmun. 1989 Jun;2 Suppl:45-53. PubMed Mitchison TJ, Kirschner MW. Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability. Cell Biophys. 1987 Dec;11:35-55. PubMed Full Text Mitchison TJ. Cell motility: good things from slime. Nature. 1987 Aug 20-26;328(6132):665. PubMed Vale RD, Schnapp BJ, Mitchison T, Steuer E, Reese TS, Sheetz MP. Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro. Cell. 1985 Dec;43(3 Pt 2):623-32. PubMed Belmont LD, Hyman AA, Sawin KE, Mitchison TJ. Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts. Cell. 1990 Aug 10;62(3):579-89. PubMed Mitchison TJ. Mitosis. The kinetochore in captivity. Nature. 1990 Nov 1;348(6296):14-5. PubMed Mitchison TJ, Sawin KE. Tubulin flux in the mitotic spindle: where does it come from, where is it going? Cell Motil Cytoskeleton. 1990;16(2):93-8. PubMed Hyman AA, Mitchison TJ. Modulation of microtubule stability by kinetochores in vitro. 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J Cell Biol. 1991 Aug;114(3):503-13. PubMed Wordeman L, Steuer ER, Sheetz MP, Mitchison T. Chemical subdomains within the kinetochore domain of isolated CHO mitotic chromosomes. J Cell Biol. 1991 Jul;114(2):285-94. PubMed Hyman AA, Mitchison TJ. Regulation of the direction of chromosome movement. Cold Spring Harb Symp Quant Biol. 1991;56:745-50. PubMed Reinsch SS, Mitchison TJ, Kirschner M. Microtubule polymer assembly and transport during axonal elongation. J Cell Biol. 1991 Oct;115(2):365-79. PubMed Full Text Hirano T, Mitchison TJ. Cell cycle control of higher-order chromatin assembly around naked DNA in vitro. J Cell Biol. 1991 Dec;115(6):1479-89. PubMed Mitchison TJ. Actin based motility on retraction fibers in mitotic PtK2 cells. Cell Motil Cytoskeleton. 1992;22(2):135-51. PubMed Sawin KE, Mitchison TJ, Wordeman LG. Evidence for kinesin-related proteins in the mitotic apparatus using peptide antibodies. J Cell Sci. 1992 Feb;101 ( Pt 2):303-13. PubMed Theriot JA, Mitchison TJ, Tilney LG, Portnoy DA. The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization. Nature. 1992 May 21;357(6375):257-60. PubMed Symons MH, Mitchison TJ. A GTPase controls cell-substrate adhesion in Xenopus XTC fibroblasts. J Cell Biol. 1992 Sep;118(5):1235-44. PubMed Mitchison TJ. Compare and contrast actin filaments and microtubules. Mol Biol Cell. 1992 Dec;3(12):1309-15. PubMed Hyman AA, Salser S, Drechsel DN, Unwin N, Mitchison TJ. Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP. Mol Biol Cell. 1992 Oct;3(10):1155-67. PubMed Sawin KE, LeGuellec K, Philippe M, Mitchison TJ. Mitotic spindle organization by a plus-end-directed microtubule motor. Nature. 1992 Oct 8;359(6395):540-3. PubMed Hyman AA, Middleton K, Centola M, Mitchison TJ, Carbon J. Microtubule-motor activity of a yeast centromere-binding protein complex. Nature. 1992 Oct 8;359(6395):533-6. PubMed Mitchison TJ, Salmon ED. Poleward kinetochore fiber movement occurs during both metaphase and anaphase-A in newt lung cell mitosis. J Cell Biol. 1992 Nov;119(3):569-82. PubMed Theriot JA, Mitchison TJ. Comparison of actin and cell surface dynamics in motile fibroblasts. J Cell Biol. 1992 Oct;119(2):367-77. PubMed Mitchison TJ. Self-organization of polymer-motor systems in the cytoskeleton. Philos Trans R Soc Lond B Biol Sci. 1992 Apr 29;336(1276):99-106. PubMed