Bill Brieher, PhD

Email: Bill_Brieher <a.t.> hms.harvard.edu

Publications Brieher WM, Coughlin M, Mitchison TJ. Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex. J Cell Biol. 2004 Apr 26;165(2):233-42. Full text Sivasankar S, Brieher W, Lavrik N, Gumbiner B, Leckband D. Direct molecular force measurements of multiple adhesive interactions between cadherin ectodomains. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11820-4. Zhong Y, Brieher WM, Gumbiner BM. Analysis of C-cadherin regulation during tissue morphogenesis with an activating antibody. J Cell Biol. 1999 Jan 25;144(2):351-9. Yap AS, Brieher WM, Gumbiner BM. Molecular and functional analysis of cadherin-based adherens junctions. Annu Rev Cell Dev Biol. 1997;13:119-46. Yap AS, Brieher WM, Pruschy M, Gumbiner BM. Lateral clustering of the adhesive ectodomain: a fundamental determinant of cadherin function. Curr Biol. 1997 May 1;7(5):308-15. Brieher WM, Yap AS, Gumbiner BM. Lateral dimerization is required for the homophilic binding activity of C-cadherin. J Cell Biol. 1996 Oct;135(2):487-96. Brieher WM, Gumbiner BM. Regulation of C-cadherin function during activin induced morphogenesis of Xenopus animal caps. J Cell Biol. 1994 Jul;126(2):519-27. McCrea PD, Brieher WM, Gumbiner BM. Induction of a secondary body axis in Xenopus by antibodies to beta-catenin. J Cell Biol. 1993 Oct;123(2):477-84. Flouret G, Majewski T, Brieher W, Wilson L Jr. Systematic substitution of an oxytocin antagonist with D-amino acids: unexpected high antagonistic potency of the D-Cys6-substituted analogue. J Med Chem. 1993 Mar 19;36(6):747-9. Flouret G, Brieher W, Majewski T, Mahan K, Wilson L Jr. Some pharmacological properties of cyclic and linear analogs obtained by substituting each residue of an oxytocin antagonist with D-tryptophan. Int J Pept Protein Res. 1991 Aug;38(2):169-75. Flouret G, Brieher W, Majewski T, Mahan K, Wilson L Jr. Improvement in potency of an oxytocin antagonist after systematic substitutions with L-tryptophan. J Med Chem. 1991 Jul;34(7):2089-94. Flouret G, Brieher W, Mahan K, Wilson L Jr. Design of potent oxytocin antagonists featuring D-tryptophan at position 2. J Med Chem. 1991 Feb;34(2):642-6.